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Wednesday, December 2, 2009

Jake Bundy

What's your position and where are you working?
For the past 5 years I have worked as a lecturer in Biological Chemistry in the section of Biomolecular Medicine at Imperial College London.

Where have you been working before?

Before this, I post-doc’ed at Cambridge; before that, UC Davis; and before that, for my first post-doc, at Imperial College again.

Briefly describe your research.
I am interested in metabolism in invertebrate and microbial species, and how this is involved in several different biological questions. Some of the projects I currently work on include microbial virulence and pathogenesis; how metabolism is affected by problems with recombinant protein folding in the bioprocessing yeast Pichia pastoris; and using earthworms as biomonitors of environmental pollution.

What do you use NMR for?
Together with mass spectrometry, I use NMR for metabolite profiling, as part of the technology for metabolomic studies. Although it’s generally less sensitive than mass spec, NMR still has a very useful role – as a near-universal and robust detector, it can give a quick and information-rich spectral profile. Most of the work we do, we just use 1D NMR for profiling; particularly useful for studies where you want to process as many samples as possible. However there are also other cases where more in-depth NMR experiments are needed, for example for isotopomer analysis to investigate metabolic fluxes; or to assign novel metabolites (essentially a natural products chemistry problem).

Which NMR software are you using?
XWIN-NMR and Topspin for data acquisition; iNMR for all NMR processing. I also use Chenomx NMR Suite for helping assign and quantitate metabolites in NMR spectra.

Which other NMR software have you used in the past?

I’ve also used VNMR and ACDLabs NMR software, and MestreC (before it was released as a commercial product).

How do you rate iNMR?
iNMR is not only my favourite NMR software for Mac OS (I’m not sure how many competitors there are at the moment), but it’s easily my favourite NMR software full stop. It’s one of a handful of Mac-only packages that I use all the time as part of my regular working day (others include Papers, Aabel, and Bookends). Features that I particularly like include the Overlay Manager (which makes it by far the quickest and easiest NMR software to use for comparing multiple spectra, in my opinion), and also the overall simplicity of using it to produce quality spectral images that can go straight into a paper or presentation without having to use multiple machines or virtualization. I admit I wasn’t really bothered by lack of anti-aliasing on spectra before using iNMR, but now I’m used to it, I do find it genuinely annoys me when looking at spectra in Topspin, say – it’s distinctly harder to see fine detail without zooming in. It’s also elegant and quick – not essential properties for software, but makes it more enjoyable to use on a regular basis.

Is it enough for your needs?
Well, it’s certainly enough for my needs in the sense that all of the spectra that I acquire are processed with iNMR – so in one sense, yes, almost by definition. It’s not 100% perfect though, there are still some small issues that could be ironed out in future releases – and as I’ve already said, I do use Chenomx software for some complementary uses which iNMR isn’t primarily designed for. I definitely see it as a crucial part of my workflow for the foreseeable future though, and expect it will keep improving (although by now it’s a relatively mature product).

Hands on 3-D Processing

A measure of the computing power available today with a desktop computer is the possibility of processing huge spectra in real time. For example: is it possible to correct the phase of a 3-D matrix interactively, in real time? The answer is: yes and you don't even have to employ more than a single core nor to buy an high-end graphic card. When I mean interactive processing I mean that:
- you see a graphic representation of the matrix at each processing stage.
- you can play with it, for example change a parameter just to see the effect it has on the matrix.
It is always necessary to know and understand the mathematical rules that govern NMR processing. The more you know them the more you enjoy their visual representations. The more you play with the graphics, the more you understand the maths behind. The two things go together.
You can find a self-teaching course on basic 3-D processing on the iNMR web site. There is no theory, only a lot of examples and a good measure of practical tips.

Thursday, November 26, 2009

Open Source NMR freeware

Most of the readers arrive here using Google, without knowing me and my blog. Usually they get very angry because they arrive... on the trapping post I wrote 3 years ago! I want to do something to keep them glad...
So you want "open source" stuff? Do you know what it really means? Are you ready to compile, test, debug it and add a graphic interface to it?
Just because you asked for it, here is a list of available projects. If you know other links, add them into a comment.

CCPN
NPK
matNMR
ProSpectND
Connjur
Newton-NMR
nmrproc
DOSY Toolbox
list of 30+ projects

Monday, November 16, 2009

Tips

It rarely happens to find valuable tips about processing on the web. When it happens, it's probably not enough to bookmark the page (it may disappear), copying it is a better idea. Here is the link:
http://spin.niddk.nih.gov/NMRPipe/embo/
When you arrive there, scroll down until you find the chapter Some General Tips About Spectral Processing.
The focus is on multi-dimensional processing with NMRPipe, but a few concepts are generally applicable indeed.
The brief discussion about first-point pre-multiplication is something to bear in mind. You can also find clearly expressed opinions on zero-filling, linear prediction and baseline correction.

Saturday, November 14, 2009

Shadow


Here is a picture I have found on the internet. I have never been in this place, if this is what you want to hear. Suppose, instead, that I live just in front of this tower and tomorrow I take a photo of it immediately after dawn, then another photo after 25 hours and so on for a week, with regular intervals of 25h between pictures. Eventually I print all the pictures in order and ask you:
"This pictures have been taken in this exact order at regular intervals. Can you tell me how long the intervals were?".
Somebody will answer: "1 hour" and the answer would be partially correct. A more correct answer would be 1 + 24 n hours, with n = 0, 1, 2, 3….
The world of FT-NMR is similar. The difference is that the regular interval between consecutive observation is known in advance while the speed of the hands and of the shadow is unknown. In other words, it is the opposite of my example of the tower.
The equivalent of a day, in the world of FT-NMR, is very very short and is called dwell time. It forms a Fourier pair, so to speak, with the spectral width. The spectroscopist sets the former, the latter is a mere mathematical consequence.
The ignorant says that the spectral width is the distance from the first point of the spectrum to the last one. This statement is as incorrect as saying that a day is made of 23 hours! The spectral width, actually, is the distance from the first point to the first point after the last one!
Let's verify it with a numerical example. Let's say we have a spectrum of 1024 points, separated by 2 Hz. If we zero-fill the FID up to 2048 points, the distance should decreases to 1 Hz. The spectral width is 2048 Hz in both cases, and this is OK. If you measure it the other way, then you have a spectral width of 2046 Hz that grows up to 2047 Hz. This is absurd, because the value is fixed at acquisition time and can't be changed by processing.
The relation is Spectral_width = 1 / Dwell_time.
Many books report another formula: Spectral_width = 1 / (2 * Dwell_time). This assumes an instrument without quadrature detection, in other words with a single detector. I have never used such an instrument.
To be exact, my whole description is dated, because today's instruments work in oversampling, the actual dwell times are shorter than what the spectroscopist sets (4 or 8 times the value reported), the FID that we see is already the result of a couple of FT (first direct, then inverse), et cetera. Seems complicated but it is not. We see what we need to see, the complications are hidden.
The important concept to remember is that the components of a digital spectrum, even if they are called "points", should be treated and conceptualized as tiles. There is no room in between. This idea will help you when you'll try to save a spectrum as a table of intensity vs. frequency. You will get the correct frequency value of each "point".

Sunday, October 25, 2009

Download Java 2 SDK, Standard Edition, v 1.4.2_04 (J2SE)

System Requirements

Software - Java 2 SDK Standard Edition, 1.4.2 is supported on i586 Intel and 100% compatible platforms running Microsoft Windows. For a list of supported operating systems and desktop managers, see System Configurations.

Hardware - Intel and 100% compatible processors are supported. A Pentium 166MHz or faster processor with at least 32 megabytes of physical RAM is required to run graphically based applications. At least 48 megabytes of RAM is recommended for applets running within a browser using the Java Plug-in. Running with less memory may cause disk swapping which has a severe effect on performance. Very large programs may require more RAM for adequate performance.

For the amount of disk space required, see Windows Disk Space Requirements.

Note -- Trying to install the Java 2 SDK on a non-supported version of Microsoft Windows or on a machine that doesn't have a sufficiently up-to-date Service Pack will cause the installer to generate this warning: "We recommend that you do not install this Java Platform for the following reasons: This Java Platform does not support the operating system or operating-system service pack on this machine."

Installation Instructions

In this procedure, you will run the self-installing executable to unpack and install the Java 2 SDK software bundle. As part of the Java 2 SDK, this installation includes the Java Plug-in and Java Web Start, as well as an option to include the public Java 2 Runtime Environment. (The Java 2 SDK also contains a private J2RE for use only by its tools.)

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Size: 92,7 mB
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OS: Windows All

Thursday, October 22, 2009

Chrno Crusade, the Fantasy Game

Playing multiplayer online game is always fantastic and adventurous, many players have join on this online games not only fun but also they can increase amount of knights as he or she increased level even they can communicate with warriors or knights that lead by him or her. This kind of multiplayer games or MMO actually have popular since 2009.

Lately, Mmo has launched the new series of adventure, AION. This is the eight-volume of manga series or you may know it as Chrno Crusade. The aion has become the hottest game that providing epic adventure through modern graphics and sounds as if real adventure to a journey world. Here, if you are seeking for information, answers, and guide to aion game you can visit Aionalliance.com. This is an online leading place that obtains nice info and community where aion players discuss and share about aion games.

Furthermore, through this site you can view topics about aion classes namely warriors, scouts, mages and priest. To understand about this class there is also class guide, which you can also read from this simply site. Aion Alliance is your premium site to aion fansite community board that you have to visit to get more knowledge and strategy to successful play.

Blog Advertising Network

Earning money from blog advertising network is easy and interesting. You might acquaint with blog advertising method, which lately become one of pledge businesses whit largest members from across the world. If you one of people who currently seeking for this information and eager to join on this opportunity, then you need a good direction which can deliver you to better blog advertisement network or company.

Blogadvertisingstore.com is one of best websites, which you can enter to view some valuable information about blog advertising network. This opportunity is not only for advertisers but also for bloggers to gather build marketplace procedure and correct type of blogger to endorse their products. From this site, you can also join or login as member of blogger and get ready to advertise on blogs and get paid for writing honest reviews.

Blog believes as effective way for business owner to develop and broaden their product reviews and increase amount of customers. Blog advertising network of Blog Advertising Store can be your last option to join in blog earn money through reviews you made. Through the website, you can also read related articles about it, which you can take as online guide to understand their offering opportunity. Think about this fun way to obtain money in simply fast and simple.

Things That You Can Do In the Garden

Month of November has also known as a good month for gardening. You might one of people who enjoy gardening and attracted to always make your garden in beautiful look, but somehow you do not have much time previously. Next month can be your finest time to do things on your garden and if you are confused about what things that you can do in the garden, the information below can be your inspiration.

Planting trees or fruits are fun you can start with remove the top layer to form a small channel and then dig over the soil at the bottom of the channel adding compost. Repeat and fill the first channel with the top soil from the second, the soil from the fist channel then plugs in the last channel. Alternatively, you can cut away any dead trail in fruit trees and clear areas of your garden and make sure that young trees well maintained with stakes to prevent from strong winter winds.

Other options that you can plant in your garden are vegetables like potatoes or garlic offering good opportunity in November. This information is one of articles that you can read easily through online articles website, there are plenty of articles, which you can read this site such as topics about education, life style, home furniture, gadget, technology, health, gardening, and many more articles. Consider this website as your best place to search for alternative, resources or recommendation in life issues.

Wednesday, October 21, 2009

Trigonometry for Dummies


This is a doublet of doublets. If you move one doublet towards the other, for example by increasing the smaller J, the central peaks will coalesce into a single peak of double intensity (the algebraic sum of the central peaks).


A triplet is a special case of doublet of doublets (the Js are identical).


Another doublet of doublets. This time the smaller coupling is anti-phase.
If we increase the small J, we'll see another algebraic addition.


This is a triplet. Right?

Tuesday, October 20, 2009

NMR for Dummies

Here is where the real fun begins. I was not joking with my previous post. You can really do these things at home. The simple instructions are available on another site, and they are illustrated. After completing the tutorial (it takes 5 minutes in total) a working application will remain in your hard disc, and you will be free to apply the same treatment to your own spectra.
iNMR has always been available as a free download (since 2005). Access is unlimited and the program never expires. Other specialized simulation modules are included to cover most of the needs of an advanced spectroscopist (the few exceptions are motivated by the fact that other needs were already covered by existing freeware).
My blog is three years old. Half of the comments have been dedicated to a single post, which is clearly (and purposely) the least representative of the blog. When people find something useful (and this is certainly the case today) and free, they don't comment.
If you are not going to comment, I will comment by myself.
COMMENT: although it's a serious work, although it contains a lot of maths (and maybe just for this reason) it's funny too.

Friday, October 16, 2009

Try this at home

Returning to the DQF-COSY of taxole, I have found this challenge:

I couldn't tell which kind of multiplet it was. I have extracted the section corresponding to the red line and moved it into my novel simulator. Then I have introduced 3 couplings and pushed the "Fit" button.

That's all. The goodness of the fit is convincing. It is a doublet of doublets of doublets and the Js are: 14.7, 6.4 and 9.9 Hz. The latter corresponds to an antiphase coupling. Not only I know which kind of multiplet it is, I have also measured the Js!
You might feel it's funny, I find it amazing, perhaps somebody will say it is useful. "The coupling constants were extracted from the DQF-COSY by the blogger's simulator".

Digitization

I am continuing my explorations on board of my new multiplet simulator. It has been easy to simulate an asymmetric doublet. Here the asymmetry is only apparent and is due to the limited digitization.

As explained yesterday, the black line belongs to an experimental 2-D spectrum (today I have chosen a TOCSY), the red line is a theoretical doublet acquired and processed under the same conditions.
My simulator allows me to change the frequency by dragging the blue label at the bottom.

In this way the coupling remains constant. It turns out that my spectrum was a middle-range case. With a slight increase of the chemical shift I can obtain a symmetric doublet, or even a singlet!

Thursday, October 15, 2009

Copy Watch

Designer watches have been reigning over the hearts of the watch lovers for a long time now. The marvelous designs and unparalleled sophistication f the designer watches make them the most revered watches on the planet. The watch designs have been endowed with timeless elegance. The traditional excellence and the inventive genius of the watch designers combine in these watches, each watch giving a new dimension to horology. Prestigious designer and luxury watches serve more purposes than mere time keeping. They serve as the ultimate status symbol. These beautiful timepieces are often worn as accessory or a piece of jewelry.

The timepieces offered by the prestigious watch brands are often so expensive that it is almost impossible to buy them without giving a fatal blow to ones savings. For those who do not wish to spend a fortune over a watch, the replicas present a smarter option. The designer watch replicas are high quality copy watches with all the high-end features of the authentic timepieces. The copy watch is a perfect clone of the authentic designer watch. Apart from looking identical to the original, it also gives a similar feel and satisfaction. The fully functional and highly accurate copy watch comes for a price much lower than that of the authentic designer watch.

The making of copy watches is strictly regulated to ensure that only the best quality watches are produced. Equipped with high quality mechanical or quartz movement, the watches are functional and dependable. Every copy watch is decorated and assembled with hand. All the copy watch components are made up of good quality material. All the watch features are kept identical to the original. The watches thus produced are exact look-alikes of the authentic designer watches.

Friday, August 14, 2009

Adobe PhotoShop CS4 11.0.1

Adobe Photoshop software, the professional image-editing standard and leader of the Photoshop digital imaging line, delivers more of what you crave. Groundbreaking creative tools help you achieve extraordinary results. Unprecedented adaptability will let you custom-fit Photoshop exactly to the way you work. And with more efficient editing, processing, and file handling, there's no slowing you down.

Create with unmatched power

Timesaving file handling with Adobe Bridge (formerly the File Browser)

Multitasking
Take advantage of compact floating mode in Adobe Bridge to process images while simultaneously working in Photoshop.

Viewing options
Easily browse your Adobe Creative Suite and other graphics files in Adobe Bridge; present your images with features like Slideshow and Filmstrip mode; scale thumbnails to any size using a slider; and view and edit metadata.

Automated batch processing
Automatically process batches of images in Adobe Bridge to rename, convert format, adjust exposure, create a web gallery or Adobe PDF Presentation, and more.

Rating and labeling
Quickly rate and label photos in Adobe Bridge so you can instantly bring up your best shots.

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Size: 814 mB
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OS: Windows XP / Vista

FreeZ Online TV 1.20

FreeZ Online TV program that can receive over 500+ free online channels of daily and live broadcasts from around the world. There is no need for a PC TV card because the TV channels are streamed through your Internet connection.

It allows watcher to watch directly into TV. You can watch in regular or full-screen mode. This software comes with automatic TV station updates so it will never be out of date. Watch TV online anywhere, anytime all from the comfort of your PC.

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Size: 878 kB
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OS: Windows All

Avira Antivir Virus Definition File Update August 14, 2009

Avira AntiVir PersonalEdition Classic is a comprehensive, easy to use antivirus program, designed to offer reliable virus protection to home-users only. Avira PersonalEdition Classic constantly and rapidly scans your computer for malicious programs (such as viruses, Trojans, backdoor programs, hoaxes, worms, dialers etc.), monitoring every action executed by the user or by the operating system and being able to react promptly when a malicious program is detected. Actions include repair, delete, block, rename and quarantine programs or files.

Avira PersonalEdition Classic also features enhanced protection against unknown boot-sector viruses, issuing alerts for boot sectors suspicious formats. Through the permanent update of the detection engine, the protection is ensured constantly: the user can set the product to download any updates when available, thus keeping you clean and safe.

Download the Virus Definition File to always keep Avira AntiVir up-to-date.

Manual Update of AntiVir
Please go through the following steps to update your AntiVir Personal Edition Classic / Premium on a PC without internet access.

· Download the latest virus definition file (IVDF) on a PC with internet access.
· Copy the downloaded file to a portable media storage such as an USB Stick or a CD-ROM for transferring it to the PC without internet access.
Note: Extracting of the ZIP file is not necessary.
· Insert the media storage into the PC without internet access.
· Start AntiVir Personal Edition Classic / Premium and go the menu �Update" and select �Manual Update".
· Select the downloaded IVDF file from your media storage and click �open".Your AntiVir PersonalEdition Classic / Premium is now up to date.

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Size: 27 mB
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OS: Windows All

Messenger Plus! Live 4.82.368

Messenger Plus! Live is a plugin for Windows Live Messenger that will add lots of features and extras that make your instant messenger easier, more useful or just tons more entertaining.

Here are some key features of "Messenger Plus! Live":

Tabbed chats:
· Use a tabbed web browser? Even if you don't, you might find tabbed conversations useful for organizing your chats by converting a myriad of windows into a simple single one. Vertical tabs on the left, normal tabs on the top. You name it. You can also use tabs to group just some special chats and keep all the rest in normal windows if you want.

Quick Texts:
· Tired of always typing the same? Meet quick texts and text replacements: automatic and customizable messages that can be sent with a simple shortcut or typed command, or automatic text replacing to use written shortcuts or using it as a word filter.

Custom Sounds:
· The Custom Emotion Sound feature brings sound integration in Messenger to the next level by allowing users to send their own sounds during a conversation. Sounds are played instantly on both ends and are transferred automatically and transparently when needed.
· New emotion sounds can be easily created from existing sound files (such as MP3s) or can be recorded live from a microphone or other audio source but, if sound authoring isn't your thing, thousands of sounds can be found in the public database or imported from sound packs.

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Size: 5 mB
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OS: Windows All

Norton AntiVirus 2010 17.0.0.65 Beta / 2009 16.5.0.135

Norton AntiVirus 2010 will be the fastest and lightest malware scanner Symantec has ever delivered. The Norton AntiVirus application scans faster and uses less memory than any other antivirus product on the market. Unlike free solutions from Microsoft, Norton AntiVirus includes intrusion detection to detect malicious code hidden in web sites before it can strike.

And Norton AntiVirus’s pulse updates ensure that you are always plugged into Symantec’s global security grid and you are never more than a few minutes away from the latest update. Improved Norton Safe Web technology blocks Internet threats before they can infect your PC. So you can browse, buy and bank online with confidence. Plus, unlike other antivirus products, Norton AntiVirus 2010 provides easy-to-understand threat and performance information to help you avoid future threats and keep your PC running

Key Benefits
Stops viruses, worms, spyware, bots, and more—Keeps your system protected against all types of malicious threats.
Norton Insight—Delivers innovative intelligence-driven technology for faster, fewer, shorter scans.
Rapid pulse updates every 5 to 15 minutes—provides up-to-the-minute protection.
Prevents virus-infected emails and instant messages from spreading—Feel secure while you keep in touch.
Blocks browser exploits and protects against infected Web sites

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Size: 28.9 mB
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OS: Windows XP / Vista / 7

Norton AntiVirus Virus Definitions August 14, 2009

Signature file updates ensure that your PC is protected from the latest viruses. It is very important to make sure that you have the latest signature on your PC.

As new threats emerge, Symantec immediately builds new Virus Definitions Updates and makes them available for download.

Note: The i32 Intelligent Updater package cannot be used to update Symantec AntiVirus Corporate Edition 8.0, 9.0, or 10.0 servers or Norton AntiVirus Corporate Edition 7.6 servers, but can be used to update Corporate Edition clients. The x86 Intelligent Updater package can be used to update Corporate Edition clients and servers.

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Norton Internet Security 2010 17.0.0.65 Beta / 2009 16.5.0.135

Norton Internet Security was designed to be the fastest virus, spyware and internet protection you can buy. The Norton Internet Security main window acts as a security management interface.

Norton Internet Security 2010 will be the fastest and lightest security suite Symantec has ever delivered. It guards your PC, network, online activities and your identity with innovative, intelligent detection technologies optimized to combat today’s aggressive, rapid-fire attacks. Improved Norton Safe Web technology blocks Internet threats before they can infect your PC.

So you can browse, buy and bank online with confidence. It even warns you of unsafe web sites right in your search results. Plus, unlike other Internet security suites, it provides easy-to-understand threat and performance information to help you avoid future threats and keep your PC running fast.

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Size: 42 mB
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OS: Windows XP / Vista / 7

Seven Transformation Pack (formerly Vista Transformation Pack) 2.0

Seven Transformation Pack will convert your XP based system to look like Windows 7 and some of its features emulated. You don't have to purchase Windows 7 or any 3rd-party applications to get Windows 7 UI experiences. This transformation pack will simply make it done for you for free! This will update your Windows XP and Windows Server 2003 with Windows Seven GUI by adding some themes and replacing system files. Seven Transformation Pack gives to your system the fresh and cool look of Microsoft's new operating system: Windows 7. The pack changes most of the system icons, skins and toolbars and also adds new enhancements to your desktop.

What's New in This Release:
· Added Superbar tweaks for sleek and groupped taskbar item
· Added Windows 7 new wallpaper
· Added Windows 7 user pictures
· Fixed scrnrdr.exe application for being reported as malware
· Fixed WindowBlinds skin detection bug in Welcome Center
· Removed LClock as it doesn't fit new taskbar UI anymore
· Removed Styler toolbar as it becomes obsolete with ViSplore
· Removed VisualTooltip due to its glitches caused with the system
· Updated battery tray icon
· Updated logon screen with horizontal account list.
· Updated logon startup branding to Windows Seven
· Updated Vista Rainbar's default background to transparent (without border)
· Updated theming engine to apply themes and automatically
· Updated system to load/save configuration for Personalization
· Updated Transformation Destination information context for better understanding
· Updated TrueTransparency to version 1 with SevenStyle skin
· Updated user account's optimization settings
· Updated ViSplore with Windows Seven skin
· Updated ViStart to ve...

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Size: 20.4 mB
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OS: Windows XP / 2003

ZoneAlarm with Antivirus 9.0.011.000 Beta / 8.0.400.020

ZoneAlarm Antivirus includes both Antivirus and the award-winning Firewall. It prevents and disables most recent and sophisticated viruses and PC attacks. NOTE: To evaluate the Beta version you need to register and account here.

Here are some key features of "ZoneAlarm with Antivirus":

Anti-Virus:
· New antivirus engine stops, blocks, and removes attacks before they infect your PC.

Operating System Firewall:
· OSFirewall monitors installation, registry and file changes - spotting and stopping all suspicious behavior.

2-Way Firewall:
· Proactively protects against inbound and outbound attacks while making you invisible to hackers.

Auto-learn:
· Automatically configures security settings based on your behavior.

Additional Layers:
· Multiple layers of advanced protection for unsurpassed security.

Fast & Easy:
· New interface that delivers a simple overview, One-click "Fix It" buttons and customization controls for more advanced users.

Requirements:
· 1 GHz 32-bit processor
· Minimum system RAM: 1GB RAM
· 250MB of available hard disk space
· Internet access

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Size: 62.3 kB
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OS: Windows XP / Vista / XP X64 / Vista64 / 7

SP3 UxTheme Patcher 1.3

The SP3 UxTheme application was designed to be a little tool that will help the user create his own unsigned themes ready to use on the new Service Pack 3 install. Note: Some antivirus and antispyware programs flag SP3 UxTheme Patcher as being infected/malware, although the application is perfectly safe and does not pose a threat to your system. This is called a 'false positive'. The term false positive is used when antivirus software wrongly classifies an innocuous ( inoffensive ) file as a virus. The incorrect detection may be due to heuristics or to an incorrect virus signature in a database. [Similar problems can occur with antitrojan or antispyware software.]

Requirements:
· Windows XP SP3 RTM version 5512

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Size: 420 kB
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OS: Windows XP

µTorrent 2.0 Build 16126 Beta / 1.8.4 Build 16150 RC / 1.8.3 Build 16010 Stable

Most of the features present in other BitTorrent clients are present in µTorrent, including RSS auto-downloading, bandwidth prioritization, Mainline DHT and scheduling (compatible with BitComet). Additionally, µTorrent supports the Protocol Encryption joint specification ) and peer exchange. µTorrent was written with efficiency in mind. Unlike many torrent clients, it does not hog valuable system resources - typically using less than 6MB of memory, allowing you to use the computer as if it weren't there at all. Additionally, the program itself is contained within a single executable less than 170 KB in size. Various icon, toolbar graphic and status icon replacements are available, and creating your own is very simple. µTorrent also has support for localization, and with a language file present, will automatically switch to your system language. If your language isn't available, you can easily add your own, or edit other existing translations to improve them! The developer puts in a lot of time working on features and making things more user-friendly. Releases only come out when they're ready, with no schedule pressures, so the few bugs that appear are quickly addressed and fixed

Here are some key features of "µTorrent":
· Multiple simultaneous downloads
· Configurable bandwidth scheduler
· Global and per-torrent speed limiting
· Quick-resumes interrupted transfers
· RSS Downloader
· Trackerless support (Mainline DHT)

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Size: 276 kB
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OS: Windows All

Nero 9 Free 9.4.12.3

Enjoy basic data burning and copying capabilities for your CDs and DVDs! With Nero 9 Free you'll be able to easily create or copy data discs while making minimal changes to the default settings of the application. You can simply load the files and press burn to make a new disc on the spot!

Requirements:
· Internet Explorer 6.0 or higher.
· 1 GHz Intel Pentium III or equivalent AMD and Intel processor
· 2 GHz Intel Pentium 4 or equivalent AMD and Intel processor for Windows Vista
· 256 MB RAM
· 512 MB RAM for Windows Vista
· 270MB hard drive space for a typical installation of all components.
· 500MB hard drive space temporary for the installation
· CD or DVD recordable or rewritable drive for burning.
· DirectX 9.0c revision 30 (August 2006) or higher.
· Up to 9 GB available hard drive space for DVD images and temporary DVD files.
· Graphics card with at least 32 MB video memory
· minimum resolution of 800 x 600 pixels
· 16-bit color settings
· 24-bit or 32-bit true color is recommended

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Size: 54.5 mB
Publisher: Visit Website
OS: Windows XP / Vista / XP X64 / Vista64 / 7

TVUPlayer 2.4.7.2

TVUPlayer is a free program that enables viewers to watch high quality live Television programs around the world. TVU networks brings you programs from around the world that you can't get from your local cable and satellite providers. Note: Some antivirus and antispyware programs flag TVUPlayer as being infected/malware, although the application is perfectly safe and does not pose a threat to your system. This is called a 'false positive'. The term false positive is used when antivirus software wrongly classifies an innocuous ( inoffensive ) file as a virus. The incorrect detection may be due to heuristics or to an incorrect virus signature in a database. [Similar problems can occur with antitrojan or antispyware software.]

Requirements:
· Windows Media Player 10 or later version is strongly recommended.

Article Source
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Size: 5.1 mB
Publisher: Visit Website
OS: Windows 2K / XP / 2003 / Vista

WinMend Folder Hidden 1.3.1

WinMend Folder Hidden is a file / folder hiding tool. While ensuring the absolute system safety, this application can quickly hide files and folders on local partitions and/or on removable devices. The hidden files / folders will be safely hidden whether the drive is accessed in another operating system on the same computer or reinstalled on another computer. You can set a password for this application. Hidden data can be displayed and unhidden only when the user enters the valid password. The data is completely invisible to other programs or on other operating systems.

Requirements:
· 800mhz CPU
· 256MB RAM
· 12 MB of free hard disk space.

Article Source
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Size: 1.6 mB
Publisher: Visit Website
OS: Windows 2K / XP / Vista / 7

FileZilla 3.2.7

FileZilla is designed as a small but powerful FTP client with many features. FileZilla includes a site manager to store all your connection details and logins as well as an Explorer style interface that shows the local and remote folders and can be customized independently. FileZilla offers support for firewalls and proxy connections as well as SSL and Kerberos GSS security. Additional features include keep alive, auto ascii/binary transfer and more. A nice program for beginners and advanced user alike.

Here are some key features of "FileZilla":
· Ability to resume Uploads/Downloads (if the server supports it)
· Custom Commands
· Site Manager with folders
· Keep Alive system
· Timeout detection
· Firewall support
· SOCKS4/5 and HTTP1.1 Proxy support
· SSL secured connections
· SFTP support
· Upload/Download Queue
· Drag&Drop
· Multi-language support
· GSS authentication and encryption using Kerberos.

Article Source
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Size: 3.9 mB
Publisher: Visit Website
OS: Windows All

GTK+ 2.16.4

GTK+ is a multi-platform toolkit that will help developers easily create graphical user interfaces. Offering a complete set of widgets, GTK+ is suitable for projects ranging from small one-off projects to complete application suites. GTK+ is free software and part of the GNU Project. However, the licensing terms for GTK+, the GNU LGPL, allow it to be used by all developers, including those developing proprietary software, without any license fees or royalties.

GTK+ is based on three libraries developed by the GTK+ team :
· GLib is the low-level core library that forms the basis of GTK+ and GNOME. It provides data structure handling for C, portability wrappers, and interfaces for such runtime functionality as an event loop, threads, dynamic loading, and an object system.
· Pango is a library for layout and rendering of text, with an emphasis on internationalization. It forms the core of text and font handling for GTK+-2.0.
· The ATK library provides a set of interfaces for accessibility. By supporting the ATK interfaces, an application or toolkit can be used with such tools as screen readers, magnifiers, and alternative input devices.

GTK+ has been designed from the ground up to support a range of languages, not only C/C++. Using GTK+ from languages such as Perl and Python (especially in combination with the Glade GUI builder) provides an effective method of rapid application development.

Article Source
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Size: 8.2 mB
Publisher: Visit Website
OS: Windows Windows 2K / XP / 2003 / Vista / XP X64 / Vista64

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Sunday, March 1, 2009

Compact & Fast Image Viewer - WildBit Viewer 5.4 Alpha 3.0



WildBit Viewer

   WildBit Viewer is compact & fast image viewer with slide show and editor. Eye catching interface within blazing fast folder, file list and thumbnail viewer. Viewer includes also Image Info with Image EXIF meta data JPEG and TIFF support and IPTC (IIMV4) information (like PhotoShop file info) from JPEG and TIFF, Thumbview has changeable views, sorting and thumbnail predefined sizes for fast thumbnail size setting.

   WildBit Viewer also includes shell toolbar, you can drop your favorite folder there and use it as an organizer. It also includes image compare. In Compare you can compare images side-by-side. In Favorites you can save list of favorite images and load list later on and you can create custom show in to Slide Show also that list you can edit with Custom Show List Editor. With Slide Show you can view images within 172 different transition effects. Slide Show includes now multi-monitor support for fast switching between two monitors. WildBit Viewer supports all major graphic formats including BMP, JPEG, JPEG 2000, GIF, PNG, PCX, TIFF, WMF and TGA (about 70 formats).


Website to download - http://www.wildbit-soft.fi/software.html

Friday, January 30, 2009

A powerful system information tool for Windows - HWiNFO32



HWiNFO32 are professional hardware information and diagnostic tools supporting latest components, industry technologies and standards. Both tools are designed to collect and present the maximum amount of information possible about computer's hardware which makes them suitable for users searching for driver updates, computer manufacturers, system integrators and technical experts as well. Retrieved information is presented in a logical and easily understandable form and can be exported into various types of reports. 

Website to download - http://www.hwinfo.com/

Thursday, January 29, 2009

Simple Flowcharts and UML Editor - Diagram Designer 1.21



Simple vector graphics editor for creating flowcharts, UML class diagrams, illustrations and slide shows.

Features include:
  • Customizable template object palette.
  • Spellchecker (see below about dictionaries).
  • Import/export WMF, EMF, BMP, JPEG, PNG, MNG, ICO, GIF and PCX images.
  • Slide show viewer.
  • Simple graph plotter to plot mathematical expressions.
  • Advanced "pocket" calculator with equation solver.
  • MeeSoft Image Analyzer integration for bitmap image editing and extended file format support.
  • Uses compressed file format for minimizing drawing file size.

Website to download - http://meesoft.logicnet.dk/

Latest Version of Gmail Backup 0.106


This is the next release of the GMail Backup tool - the ultimate one-click solution for doing backups of your GMail account.

Here is the changelog of this version:

  • Filenames now uses only characters allowed by operating systems. It avoids many errors reported in our Forum or directly to us. Thank you for bugreporting!
  • Many other errors were fixed, for example [1], [2] and others.
  • Gmail Backup is now translated into Russian, Dutch and Danish. Special thanks to Alex Kachanov, Lode Vlayen and Lennart Christiansen. Can somebody test these localization? And is there somebody who would like to translate Gmail Backup into his language? Don't hesitate and write us.
  • This version contains only bugfixes since the last release 0.105. It is strongly recommended to use this version.

Website to download - http://www.gmail-backup.com/

Wednesday, January 28, 2009

Quick and Effective Way to Restore Files - Undelete Plus 2.98



Undelete Plus is a quick and effective way to restore accidentally deleted files. It can also recover files that have been emptied from the Recycle Bin, permanently deleted files within Windows using the Shift + Delete, and files that have been deleted from within a Command Prompt.

Undelete Plus works under Win 95/98/Me/NT/2000/XP/2003/Vista operating systems. The program supports all Windows file systems for hard and floppy drives including FAT12/16/32,NTFS/NTFS5 and image recovery from CompactFlash, SmartMedia, MultiMedia and Secure Digital cards.

Website to download - http://www.undelete-plus.com/

Extract MP3 from Video for Free - Video MP3 Extractor 1.8

Video mp3 Extractor is easy to use tool to extract audio from Video AVI, ASF, WMV files. Output audio file is mp3, and you can listen extracted audio with your mp3 player without any additional conversion or modification. Video mp3 Extractor provides simple and fast method to rip audio from video and save as MP3.

The main features include:

- Convert Video Files directly to mp3

- No additional software required

- Fast audion extraction algorithm

- Easy to use interface.


Website to download - http://www.geovid.com/Video_mp3_Extractor/